Opioid pharmacodynamics and pharmacokinetics: Knowing the difference
Pharmacists in community-based practice.
Universal program number: 0401-0000-17-056-L01-P
CE Broker tracking number: 20-573853
Activity type: Knowledge-based
Date: Tuesday, June 20 from 8:00 p.m. - 9:00 p.m. EDT
It has been postulated that part of the blame for the current opioid crisis is due to clinicians who entered into a pain management role, but who lacked a thorough understanding of pain etiology/pathology and opioid pharmacology, often believing that, aside from some subjective differences, all opioids are created equal. The major opioids used in pain management differ not only pharmacokinetically, but at the pharmacodynamic level as well. In this session, we will briefly review pain pathology and then examine the PK and PD differences between the most commonly used opioid analgesics and where these differences may negatively affect clinical outcomes in select patients. We will conclude by discussing the importance of communication between pharmacists and prescribing clinicians regarding prescribed drug choices, doses, etc., in certain patients.
- Review the pathophysiology of pain, including the various types and those most/least amenable to opioids.
- Compare and contrast the pharmacodynamics and pharmacokinetics of the most common opioids used in pain management.
- Identify which opioids may be affected by renal and/or hepatic impairment as well as drug interactions and the potential clinical impact.
- List the number of rationales for opioid rotation.
- Define incomplete cross-tolerance and its importance in equianalgesic dose calculations.
To obtain credit:
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Drug Store News is accredited by the Accreditation Council for Pharmacy Education (ACPE) as a provider of continuing pharmacy education. This CPE activity is approved for pharmacists and is worth 1.0 contact hours (0.1 CEUs).
Alan P. Agins, PhD, president, PRN Associates, continuing medical education, Tucson, Ariz.
Alan P. Agins and the DSN editorial and continuing education staff do not have any actual or potential conflicts of interest in relation to this lesson.
- 1.00 Pharmacist